Configure Nginx to Serve a Node.js Express App

This nginx server block is configured to proxy the node application.
Mind the server port, set to 3300 in this example.

In order to properly run a Node.js application in production,
have a look here

Nginx config for node.js

server {
  listen 80;
  root /var/www;      # trivial here
  index index.html;   # trivial either
  server_name node.site.com

  location / {
    proxy_pass http://127.0.0.1:3300;  # or the server running node
    proxy_http_version 1.1;
    proxy_set_header Upgrade $http_upgrade;
    proxy_set_header Connection 'upgrade';
    proxy_set_header Host $host;
    proxy_set_header X-Real-IP $remote_addr;
    proxy_set_header X-Fowarded-For $proxy_add_x_forwarded_for;
    proxy_set_header X-Fowarded-Proto $scheme;
    proxy_cache_bypass $http_upgrade;
  }
}